Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

ROLE OF URIC ACID IN PREDICTING THE DECREASE OF RENAL FUNCTION IN NORMAL AND DIABETES SUBJECTS

Author

Laurentius Aswin Pramono, Pradana Soewondo, Sarwono Waspadji

Institution

Department of Internal Medicine University of Indonesia

Abstract

Objectives: Hyperuricemia has been known to be associated with diabetes and kidney disease. The aim of this study is to find the correlation between uric acid and decrease of renal function in normal and diabetes subjects, as a study to find predictor which can controlled by medications – that related with diabetic nephropathy event.

Methods: The study was done using cross-sectional method, obtaining secondary data from National Basic Health Research survey conducted in 2007. Uric acid is candidate for predictor, while renal function is represented by estimated creatinine clearance rate (eCCr) using Cockcroft-Gault formula. This variable’s cut off criteria uses the international standards; International Society of Nephrology criteria for chronic renal disease.

Results: Among 17.638 subjects in the study, we find that uric acid is significantly correlated with estimated creatinine clearance rate (eCCr) in Indonesian normal subjects (p<0.0001) and diabetes subjects (p<0.0001).

Conclusion: Uric acid is correlated with decrease of renal function in normal and diabetes subjects. This modifiable variable can potentially be strong predictor for renal complication in diabetic patients.