Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

FACTORS AFFECTING ADHERENCE LEVEL TO HAART (ADHERENCE PREDICTORS) IN A MAJOR HOSPITAL IN KUALA LUMPUR, MALAYSIA

Author

Umar Y Mohammed 1 , Awang M Bulgiba 1 , Zamri Chik 2 , Christopher Lee 3 , Devi Peramalah 1

Institution

1. Julius Centre University of Malaya, Department of Social and Preventive Medicine, Faculty of Medicine, University Malaya
2. Department of Pharmacology, Faculty of Medicine, University Malaya
3. Department of Medicine, Sungai Buloh Hospital

Abstract

Objectives: Adherence to Highly Active Antiretroviral Treatment (HAART) is currently the most important factor in predicting HIV positive patients’ treatment outcome. Many factors such as medication side effects (vomiting), factors facilitating adherence (Use of Alarm clock) and reasons for missing medications (stigma) may affect the adherence level. Objectives: To examine the key factors that can affect the adherence level as measured using a self-reported adherence questionnaire.

Methods: A total of 925 infected patients who were on antiretroviral treatment were recruited in a prospective cohort study using an overall self- reported adherence questionnaire. A logistic regression model was developed based on the instrument.

Results: Overall adherence level to HAART was 81.7 %. Predictors of adherence were diarrhoea (OR 0.081; 95% CI 0.034, 0.192), vomiting (OR 0.131; 95% CI 0.058, 0.294), use of alarm clock (OR 6.712; 95% CI 2.747, 16.397), acceptance of HIV status (OR 4.727; 95% CI 1.960, 11.403), simply forgot (OR 0.080; 95% CI 0.033, 0.197) and educational level (OR 1.430; 95% CI 1.108, 1.844). Thirty-two other factors were significant predictors of adherence level to HAART.

Conclusion: Side effects of drugs and simply forgetting adversely affect adherence to HAART but the use of alarm clocks, getting patients to accept their HID condition and a higher educational level improved the likelihood of adherence to HAART.