Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

PREDICTORS OF SURVIVAL IN MALAYSIAN HIV INFECTED PATIENTS ON ANTI- RETROVIRAL THERAPY

Author

Rahayu Lubis 1 , Awang M Bulgiba 1 , Adeeba Kamarulzaman 2 , Noran N Hairi 1 , M Dahlui 1 , Devi Peramalah 1

Institution

1 Julius Centre University of Malaya, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
2 Infectious Disease Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

Abstract

Objectives: To determine the predictors of survival in Malaysian HIV infected patients undergoing antiretroviral therapy (ART) in the University of Malaya Medical Centre

Methods: HIV patients on ART age = 20 years as participant. Analysed data from a bidirectional cohort study in which patients were followed up from 1989 to 2009, Kaplan Meier and Cox regression analysis were used

Results: A total of 845, the majority aged 20-39 (70.4%), male (78.2%), Chinese (67.3%), heterosexual (75.0%), had opportunistic infection (78.8%), CD4 < 200 (82.7%) and VL = 100000 (62.1%). 71.9% had triple drugs, 14.0% changed to PI and 61.5% achieved VL = 50 copies/ml. Predictors of survival were aged 50-59 (HR 2.27; 95% CI 1.42, 3.63), AIDS (HR 5.75; 95% CI 3.29, 10.07), secondary education (HR 3.57; 95%CI 1.12, 11.37), tertiary education (HR 3.57; 95% CI 1.09, 11.70), unemployed (HR 1.49; 95% CI 1.07, 2.09), manual worker (HR 1.24; 95% CI 0.85, 1.89), single drug (HR 1.84, 95% CI 1.27, 2.66), double drug (HR 1.63, 95% CI 1.19, 2.25) and inability to achieve VL = 50 copies/ml (HR 10.22; 95% CI 7.26, 14.37).

Conclusion: Socio-demographic, AIDS presentation, initial ART are predictors of survival and achieving VL = 50 copies/ml is indicates the effectiveness of ART