Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

A GENETIC VARIANT IN MIR-196A2 INCREASED DIGESTIVE SYSTEM CANCER RISKS: A META-ANALYSIS OF 15 CASE- CONTROL STUDIES

Author

Jing Guo , Mingjuan Jin , Mingwu Zhang , Kun Chen

Institution

Department of Epidemiology and Health Statistics, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, China

Abstract

Objectives: The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. We want to quantify and conclude the association.

Methods: A meta-analysis based on 15 independent case-control studies consisting of 4889 cancer patients and 7606 controls was performed to address this association. Random or fixed effect models were used appropriately according to the between-study heterogeneity. By stratifying tumors on the basis of site of origin, source of controls, ethnicity and allele frequency in controls, we explored the source of heterogeneity. A meta-regression was also conducted.

Results: We found that miR-196a2 polymorphism significantly elevated the risks of digestive system cancers (CT vs. TT, OR=1.25 (1.07-1.45); CC vs. TT, OR=1.38 (1.13-1.67); CC/CT vs. TT, OR=1.29 (1.10- 1.50); CC vs. CT/TT, OR=1.14 (1.01-1.30); C vs. T, OR=1.15 (1.05-1.26). Besides, this SNP might increase the susceptibility of colorectal cancer (CRC) and hepatocellular cancer (HCC). Different subgroups showed different outcomes. While no heterogeneities from subgroups were detected evidently by meta-regression.

Conclusion: Our findings suggest the significant association between miR-196a2 polymorphism and increased susceptibility of digestive system cancers, especially of CRC, HCC and Asians.