Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

PREDICTORS OF FIVE YEAR SURVIVAL AMONG COLORECTAL CANCERS PATIENTS IN UNIVERSITY MALAYA MEDICAL CENTER, MALAYSIA

Author

Magaji BA 1 , Moy FM 1 , Roslani AC 2 , Law CW

Institution

1. Julius Centre University of Malaya, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Malaysia
2. Department of Surgery, Faculty of Medicine, University of Malaya, Malaysia

Abstract

Objectives: Colorectal cancers are a major public health problem in Malaysia. The aim of this study is to determine the predictors of five year survival among colorectal cancer patients managed at the University Malaya Medical Center (UMMC), Malaysia.

Methods: A retrospective cohort study of 762 (56.5% male and 43.5% female) patients managed at the center between 1999 and 2010 was conducted. Demographic, treatment and living status data were analyzed and presented.

Results: Mean age was 62.1(12.6) years, Chinese made up 66.5%, stage III and IV constituted 63.8%. Overall median survival was 33 months (95% CI; 67.7, 85.2). One, three and five year’s relative survivals were 74%, 48% and 37% respectively. Cox proportionate hazard models showed significant prognostic factors were: undergoing emergency operation (HR 1.60; 95% CI: 1.03, 2.47), high grade cancer (HR 1.74; 95% CI: 1.18, 2.56), stage IV (HR 6.14; 95% CI: 3.37, 11.20), and adjuvant chemotherapy (HR 1.59; 95% CI: 1.15, 2.21).

Conclusion: Colorectal cancer(s) managed at the UMMC are late stage, high grade cancers requiring adjuvant chemotherapy; thereby resulting in low overall five year survival compared to developed nations. This study confirms the needs for a national screening and education program to improve early diagnosis and survival of these cancers.