Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

IN-VIVO STUDY OF LUMBROKINASE EXTRACTED FROM LUMBRICUS RUBELLUS AS FIBRINOLYTIC IN CARDIOPROTECTIVE EFFECT

Author

Wardhana YA, Nugraha RA, Ma'rifatillah AZ

Institution

Faculty of Medicine, Airlangga University

Abstract

Objectives: Evaluation the efficacy of novel fibrinolytic agent, lumbrokinase, using in-vivo study for treatment of stable angina.

Methods: Systematic review. Trials were searched in computerized general databases by checking bibliographies and searching keywords.

Results: Lumbrokinase can inhibit progressive procoagulant activity, reflected by significant decrease (P = 0.05) in recalcification time. Clotting time was decreased from 180±10 sec to 120±8 sec. Lumbrokinase also decreased the infarct size of myocardium in patient with stable angina. Myocardial reperfusion rate of lumbrokinase at dose of 20, 40, and 80 mg kg(-1) was 8%, 35% and 47%. Subject using lumbrokinase after 7 days show no significant change in mean of PPT ratio, APTT ratio, and fibrinogen in coagulation status parameter. This means lumbrokinase is safety and doesn’t cause hemorraghic and any bleeding complication.

Conclusion: Lumbrokinase shows promising result in blood-clots lysis with minimally risk of bleeding. Further experiment with greater samples and longer duration should be done to make sure Lumbrokinase’s effect as safety trombolytic agent.