Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

SIGNIFICANT ASSOCIATION OF APOE- E4 ALLELE AND UNFAVORABLE OUTCOME AFTER TRAUMATIC BRAIN INJURY: META- ANALYSIS

Author

Poovindran AR, Ganesan D, Pancharatnam D, Wong K.T.

Institution

Faculty of Medicine, University of Malaya

Abstract

Objectives: To carry out a meta- analysis of cohort studies to assess the association between the APOE-E4 allele and 6 month outcome after traumatic brain injury (TBI).

Methods: MEDLINE database were searched for literature published from 1993 to 2011. Journals and reference lists of retrieved article were hand- searched. Information on study design, patients’ characteristics, clinical outcome, APOE-E4 allele frequencies were abstracted and a summary database developed.

Results: Of the 86 identified studies, 12 studies (4 showed significant association between APOE-E4 allele and 6 month outcome after TBI) were included. A total of 2248 patients included in this meta- analysis, 727 with and 1521 without the APOE-E4 allele. There is higher risk of unfavorable outcome at 6 month after TBI among patients with APOE-E4 allele compared to those without APOE- E4 allele (OR =1.335; 95% CI, 1.101- 1.618).

Conclusion: In patients with TBI, possession of APOE-E4 allele is significantly associated with higher risk of unfavorable outcome after TBI.