Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

GROWTH DEVELOPMENT IN CHILDREN WITH CONGENITAL HYPOTHYROIDISM: THE EFFECT OF SCREENING AND TREATMENT VARIABLES – A COMPREHENSIVE LONGITUDINAL STUDY

Author

Feizi Avat, Hashemipour Mahin, Yazdi Maryam, Hovsepian Silva, Kelishadi Roya, Amirkhani Zeynab, Amini Masoud

Institution

Isfahan university of Medical Sciences

Abstract

Objectives: To investigate the biomedical diagnostic and early treatment factors potentially affecting growth status of the patients with congenital hypothyroidism (CH).

Methods: In a longitudinal study, 760 (345 girls and 415 boys) neonates born in 2002-2010 with CH diagnosed by neonatal screening in Isfahan-Iran were followed from the time of diagnosis (i.e. 3-4 records for the first year of age and 2-3 records after that). Advanced statistical method i.e. quantile regression for longitudinal data was used for investigating the effects of main factors determining the growth development and providing empirical evidence of effects heterogeneity depending on patient location on the distribution of growth status.

Results: Longitudinal growth in height and weight was significantly correlated with the timing of onset treatment and starting dosage (p<0.01) while head circumference only with starting dose (P<0.05). Growth in height and head circumference was affected by serum TSH concentration at diagnosis (p<0.05). Also the age of T4 normalization had heterogeneous impact, over the proposed quantiles, on weight (p<0.05), height (p<0.01) and head circumference (p<0.001).

Conclusion: Among studied factors, starting dose and age of treatment initiation seem to be more important factors for growth development, suggesting that more optimal outcome might be possible through earlier treatment and appropriate levothyroxine dosage.