Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

ASSOCIATED FACTORS OF LEPTOSPIROSIS AMONG FEBRILE CASES ADMITTED TO HOSPITALS IN NORTHEASTERN MALAYSIA

Author

Noor Rafizah AA

Institution

Universiti Sains Malaysia

Abstract

Objectives: Leptospirosis is a worldwide zoonotic disease. Risk factors for the disease may vary among countries. This study was conducted to determine the associated factors of leptospirosis among febrile cases.

Methods: A hospital-based cross sectional study was conducted among 999 of febrile patients admitted to 10 hospitals in northeastern Malaysia, from August 2010 until February 2011. An interviewer-guided proforma sheet on sociodemographic, type of occupation and social history data was distributed to all adult patients with fever on admission. Serum sample for leptospirosis was screened by IgM Enzyme-linked Immunosorbent Assay test (IgM ELISA) and confirmed by Microscopic Agglutination Test (MAT). The cut-off point for positive MAT was =1:400 titre in single acute specimen.

Results: Seroprevalence of leptospirosis was 8.4% (95% CI: 6.8-10.3%) (n=84) by MAT. Multiple logistic regression analysis showed the high risk occupation group (OR: 2.05, 95% CI: 1.28, 3.26) and history of recent recreational activity (OR: 2.36, 95% CI: 1.45, 3.83) were significant associated factors for leptospirosis.

Conclusion: This study shows a relatively high seroprevalence of leptospirosis in northeastern Malaysia. Identification of those factors will help to increase the index of suspicion to diagnose leptospirosis due to its mimicking other common febrile illnesses in Malaysia.