Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

ABDOMINAL OBESITY, HYPERCHOLESTEROLAEMIA AND RISK OF COLORECTAL CANCER

Author

Ulaganathan V

Institution

Universiti Putra Malaysia

Abstract

Objectives: To determine the relationship between obesity and blood lipid with risk of colorectal cancer (CRC)

Methods: Histologically confirmed CRC patients from five local hospitals were matched with cancer free controls for age, gender and ethnicity (140: 280). Study subjects underwent physical assessment for the presence of obesity and fasting blood was drawn for blood lipid analysis

Results: Subjects with CRC were predominantly Chinese (41.4%) with a mean age of 60.8 ± 11.72 years. The mean waist circumference, body mass index, waist hip ratio, body fat percentage, fasting plasma triglycerides, HDL-cholesterol, total cholesterol and LDL-cholesterol were 87.5±13.2 cm, 24.2±5.7 kgm2, 0.9±0.1, 30.2±6.9%, 1.7±0.8 mmol/L, 1.1±0.4 mmol/L, 4.8±1.7 mmol/L and 2.9±1.5 mmol/L respectively. Abdominal obesity found significantly doubled the risk of CRC (OR=1.90, 95% CI=1.1-3.4). Hypercholesterolaemia and low HDL were also found to increase the risk of CRC (OR=2.2, 95% CI= 1.6-2.8 and OR=4.1, 95% CI=2.4-7.2 respectively). Abdominal obesity and hypercholesterolaemia synergically doubled the risk of CRC (OR=2.0, 95% CI=1.0-4.0) but not with low-HDL.

Conclusion: Decreasing abdominal obesity and hypercholesterolaemia may be clinically relevant strategy to reduce the risk of CRC and other chronic diseases.