Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

WEIGHT LOSS INTERVENTION PROGRAM IMPROVED FAT FREE MASS AND PLASMA HEPARIN COFACTOR II ACTIVITY

Author

Norsuhana Omar

Institution

Physiology Department, Universiti Sains Malaysia

Abstract

Objectives: The aims of this study were to elucidate the changes of FFM and plasma HCII activity level and to determine the correlation between these two parameters among obese subjects participating in a 12-weeks weight loss program.

Methods: Twenty-eight subjects (n=28) aged between 26 to 62 years old were involved in a weekly structured weight loss program consisted of exercise (brisk walk + low impact of aerobic dance+ dietary intervention) for 12 weeks duration. About 5 mls of blood specimen was drawn at baseline and post-intervention to determine the plasma HCII activity levels. Data were then analyzed using paired t-test to determine the mean changes of the parameters.

Results: There was a significant improvement (p<0.001) of mean FFM from 52.93±1.65 % (baseline) to 59.76 ± 1.33 % at post-intervention. Besides that, there was a significant increased (p<0.001) in plasma HCII activity level; from 105.22 ± 23.40 % (at pre-intervention) to 119.89 ± 18.93% after completion of the intervention program. There was a significant, positive and fair correlation between FFM and HC II (r = 0.32, p < 0.05).

Conclusion: This study indicates that weight loss has led to a significant improvement of FFM and plasma HCII activity. These findings supported the natural effect of weight loss program in reducing the thrombin activity in obese individuals which is closely related to vascular events.