Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

A PREVALENCE OF TOXOPLASMA GONDII INFECTION IN REMISSION STATE OF SCHIZOPHRENIA IN RELATION TO DEMOGRAPHIC PROFILE - A PRELIMINARY FINDING

Author

Nor Fatini Adam 1 , Ainsah Omar 2 , Osman Che Bakar 1 , Zulkifli Ghaus 3 , Ahmad Hatim Sulaiman 4 & Mohamad Ikhsan Selamat 1

Institution

1 Medical Faculty, UniversitiTeknologi MARA, Sungai Buloh, Selangor
2 Faculty of Medicine & Health Defence, Universiti Pertahanan Nasional Malaysia (UPNM)
3 Psychiatry and Mental Health Clinic, Sungai Buloh Hospital
4 Psychiatry Daily Ward, University Malaya Medical Centre

Abstract

Objectives: Toxoplasma gondii (Tg) infection causes psychotic symptoms resembling Schizophrenia. This study is to examine the prevalence of Tg infection in remission state of Schizophrenia in relation to demographic profile

Methods: Antibody Immunoglobulin G (IgG) was measured in 57 consecutive schizophrenia (diagnosis based on DSM IV Criteria) patients in remission state which is determined by interview the patients by using structured interview guidelines for Brief Psychiatric Rating Scale (BPRS) with the score of (<52) by serologic test which is Enzyme-Linked Immunosorbent Assay (ELISA) test from patients’ blood serum. Serum was prepared by centrifuged blood at 1300 rpm in 15 minutes and kept at -20°C for further test

Results: We found that male is higher than female with 30 (52.6%), Chinese is the highest in ethnic aspect with 24 (42.1%), the other demographic profile were unemployed 26 (45.6%), single 32 (56.1%), education level was a lower secondary school 20 (35.1%), with an income of a lower than RM500 20 (35.1%) while urban population had a higher than rural with 40 (70.2%). Toxoplasma gondii seropositive for IgG antibody was detected in 29 subjects with 50.9% and higher in male patients (16; 55.2%), but there was no significant different in terms of ethnics, unemployment and income. The significantly higher of prevalence is in single subjects with 18(62.1%) and urban residence with 21 (72.4%) p<0.05.

Conclusion: These findings show that infection of Tg is higher in schizophrenia cases towards single and urban residence subjects