Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

IN-SILICO ANALYSIS OF MISSENSE MUTATIONS IN TP53 GENE LEADING TO BREAST CANCER SUSCEPTIBILITY

Author

Suneetha. Y, Kumaraswamy Naidu C

Institution

Sri Venkateswara University

Abstract

Objectives: To prioritize Coding and Non-Coding Polymorphisms and to analyze the effect of missense mutations using molecular dynamics approach.

Methods: dbSNP, SIFT, Polyphen, Mutdb, Gromacs

Results: In-silico SNP analysis of TP53 gene revealed that SNPs, rs28934874 (P151T), rs28934571 (R249G), rs17849781 (P278A) has deleterious effect with phenotypic effect conferring to Breast Cancer. Further, these SNPs were subjected to Molecular dynamics and they are to found to deviate from their native TP53

structure.

Conclusion: Studies using SNPs to probe the genetic basis of Breast Cancer can provide insights into susceptibility, modification of the phenotype and response to pharmacologic treatment.