Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

SYNERGISTIC RISK OF HEPATITIS B AND C INFECTIONS AND HEPATOCELLULAR CARCINOMA

Author

Mohamed Salah

Institution

Occupational Medicine Unit, Collage Of Medicine, Ain Shams University, Egypt

Abstract

Introduction: Hepatocellular carcinoma is a common malignant tumor in Saudi Arabia .Chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) are causally related to hepato- carcinogenesis.

Objectives: The objective of this study is to estimate the risk of hepatocellular carcinoma (HCC) in non alcoholic patients with chronic infections of both HBV and HCV and the possible synergistic effect between the two infections. Methodology: 118 patients with HCC who were admitted to the two referral speciality hospitals in Al –Qassim region in Saudi Arabia were compared with 118 healthy individuals matched for age and sex.

Results: The prevalence rate of HBsAg in HCC patients (67%) was significantly higher than the rate in the controls (6.7%) (p<0.01). There was a higher risk of HCC in the presence of HBsAg alone (OR:23.9; 95% CI:10.1-58.9, p<0.05) and anti HCV alone (OR: 3.6; 95% CI :1.8-16.7, P<0.05). Although HBV and HCV infections were independent risk factors in the development of HCC, there was no interaction relationship between the two viruses. Combined infections occurred only in 3.4% patients and the difference between patients and control was not statistically significant. In 24.6% of the cases no virus was identified as an etiologic factor.

Conclusion: hepatitis B virus constitutes a major risk factor and hepatitis C virus play a less significant role in the development of HCC. The ongoing program of HBV vaccination my significantly decrease the prevalence of HBV- associated HCC in this population.