Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

THE RELATIONSHIP BETWEEN HELICOBACTER PYLORI INFECTION AND MYOCARDIAL INFARCTION

Author

Azarkar Z, Jafarnejad M, GH. SHarifzadeh

Institution

Medical Science University, Birjand

Abstract

Objectives: Coronary Artery Disease is known as the main cause of death in industrialized countries. Relation between this disease and some infections such as Helicobacter pylori is has been shown in several studies.

Methods: The current paper is based on a case- control study. 73 myocardial infarction patients’ and 78 individuals with no history of this disease were compared. Patients and control matched for age and sex person to person by the match method. Levels of serum IgA and IgG antibodies against Helicobacter pylori were measured by ELISA method and data were compared between two groups in terms of relation with cardiac risk factors.

Results: In this study from 151 participants, 73 were patients and 78 were control. The percentage of IgG positive cases against H. pylori was 57.5% in the case group and 32.1% in the control group which showed a statistically significant difference (P =0.002, OR: 2.87 CI: 95%; 1.5-5.6) Meanwhile, there was no significant difference in IgA positive cases between the two groups (42 .5% and 48. 7% in the case and control groups, respectively). (P = 0. 44; OR: 0/78 CI: 95%; 0.41-1.48). The study showed 74.2% of cases in the case group and 45.2% in the control group were positive for both IgG and IgA; the difference which was considered as a statically significant finding (P =0.01; OR: 3/5 CI: 95%; 1.3-9.5). No significant differences were found between two groups in terms of relation between H. pylori related antibodies level and heart disease classic risk factors, sex, and age (Except for dyslipidemia in case group, P =0.05).

Conclusion: According to the results, it seems there is a relation between Helicobacter pylori infection and myocardial infarction. This relationship can be a causal factor or a factor resonator is other risk factors.