Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

N-ACETYLCYSTEINE FOR THE PREVENTION OF CONTRAST INDUCED NEPHROPATHY

Author

Hui-Fen Hsiang

Institution

Taipei Medical University Hospital

Abstract

Objectives: To understand oral N-Acetylcysteine for prevention of CIN.

Methods: 1. Asking an answerable question: Patient/problem, Intervention, Comparison, Outcomes 2. Keyword:N-Acetylcysteine and contrast-induced nephropathy. Search Pub Med, Cochrane and CEPS database. 3. Critical appraisal and acquire the best available evidence. 4. Apply to the patient: This study is retrospective study design, select the case of a regional hospital for the collection sites, collected from 2009 to 2011 the implementation of coronary angiography patients' medical records, total had 49 cases, NAC group 20, control group 29. NAC group received oral NAC 600mg, 2 times a day (total 2400mg); control group were given saline. Two groups were given 0.9% saline, 1000mL/day.

Results: This study collected NAC group 20, control group 29, the basic properties of the distribution, various demographic characteristics, serum creatinine distribution, garnered statistically were no significant difference between the two groups. NAC group serum creatinine average 1.25 ± 1.04mg/dl; control group mean serum creatinine 1.38 ± 0.81mg/dl, There were no significant difference between both (Z =- 1.237, P =. 216). The incidence of CIN were no significant difference between the two groups (χ ² =. 002, P = 1). 2 patients in the NAC group (2 / 20: 10%) and 3 patients in the control group (3 / 29: 10.34%)

Conclusion: In this study, found that low doses of NAC does not prevent the incidence of CIN. CIN does not often occur in patients with normal renal function. This result may provide physicians to consider Cr higher cases, and then choose to give high doses of NAC for prevention of CIN.