Main Organiser

Julius Centre University of Malaya

Co-organiser

Department of Social and Preventive Medicine, Faculty of Medicine, University of Malay

Supported by

University of Malaya

EFFECTS OF TRIPLE ANTITHROMBOTIC THERAPY FOR PATIENTS WITH STENT IMPLANTATION

Author

Rongfang Chen, HuiYu Wang

Institution

Chi Mei Medical Center

Abstract

Objectives: The objective of this study was to characterize the benefits of triple antithrombotic therapy for patients with stent implantation.

Methods: Developing the PICO: Patient: Patients with acute coronary syndrome. Intervention: Dual antiplatelet therapy with warfarin. Comparison: Dual antiplatelet therapy. Outcome: Cardiovascular event. Searching strategy was addressed by using keywords as dual antipletelet, warfarin with limitations "humans, clinical trial, meta-analysis, and randomized controlled trial" in the database of PubMed, ACP Journal Club, Evidence-Based Medicine and Cochrane library. Then the result was 14 articles. Two articles were evaluated to give the final results that were meta-analysis.

Results: In the first article, outcomes of the prevention of major adverse cardiovascular events and reduction in all-cause mortality show triple antithrombotic therapy to be better than dual antiplatelet therapy. However, there was no significant difference in the incidence of ischemic stroke. In the second article, patients with triple antithrombotic regimen had significant reduction in ischemic stroke. The overall incidence of death and myocardial infarction was comparable between the two regimens.

Conclusion: Under current evidence level, we can't clearly explain to patient about the benefit. It poses imperative demands for future prospective randomized studies to define the optimal antithrombotic regimen for patients with stent implantation.